- Swim, climb, and shimmy
- Use a variety of weapons from the environment
- Use Indy's signature whip as a multi-purpose tool
- Unlock more than 60 playable characters
- Mix-and-match lego parts to create unique characters
- Collect artifacts through the game to unlock more than 60 playable characters, including villains and supporting characters; enjoy character swapping and free-play abilities along with two-player drop-in, drop-out cooperative gameplay.
- Build your own adventure mode allows you to create your own levels and environments and share them with your friends, combining them with the existing ones in the game; beat each level in Story mode and return in Free Play.
- Play all new Kingdom of the Crystal Skull characters such as Mutt Williams on his motorcycle and use special abilities, including Oxley's Crystal Skull Power.
- Indy has all new animations, such as grabbing an enemy with his whip then throwing him over his shoulder as well as using Indy's newly enhanced whip to interact with Lego objects and help unlock iconic puzzles and battle with enemies.
- Jump into all new vehicles to help Indy get through all the new levels including planes, boats and mine carts - but watch out for the quicksand; Use a variety of weapons from the environment to fight enemies (e.g., chairs, guns, swords, bottles).
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